effects of normobaric hyperoxia pretreatment on ischemia-reperfusion injury in regional ischemia model of isolated rat heart
Authors
abstract
abstract introduction: resent studies have been shown beneficial effects of hyperoxia pretreatment against ischemia-reperfusion injury in different organs. the aim of the present study was to investigate early and late effects of normobaric hyperoxia (≥95% o2) pretreatment on ischemia-reperfusion injuries in isolated rat hearts. methods: following 60 and 180 minutes of hyperoxia, rat hearts were isolated immediately (h60 and h180) or 24 hours later (h60/24 and h180/24), and subjected to 30 minutes of regional ischemia followed by 120 minutes of reperfusion. incidence and severity of ventricular arrhythmias, mechanical function of the heart and coronary flow were assessed during 120 min of reperfusion. ldh and ck release and infarct size were also assessed. results: incidence and severity of reperfusion arrhythmias significantly reduced by hyperoxia pretreatment, especially in the early phase of treanment. h180 reduced the incidence of ventricular fibrillation (vf) to 0% vs. 50% of normoxic control, p<0.05). vf duration decreased in h180 group (0 vs. 50±31s in the nc group, p<0.05) and duration of vt decreased in h60 and h180 groups compared to normoxic control group (nc) (1.5±0.7 s and 7.5±2.5 s vs. 17.7±3.3 s respectively, p<0.05). hyperoxia improves mycardial contractile function and improves coronary flow during reperfusion. infarct size and enzymes release were also significantly decreased in early and late phase of hyperoxia pretreatment. conclusions: these results indicate that hyperoxia pretreatment before induction of regional heart ischemia reduces cardiac infarct size and attenuates reperfusion induced arrhythmias in isolated rat heart. keywords: hyperoxia, ischemia-reperfusion injury, heart protection, arrhythmias
similar resources
Effects of normobaric hyperoxia pretreatment on ischemia-reperfusion injury in regional ischemia model of isolated rat heart
Abstract Introduction: Resent studies have been shown beneficial effects of hyperoxia pretreatment against ischemia-reperfusion injury in different organs. The aim of the present study was to investigate early and late effects of normobaric hyperoxia (≥95% O2) pretreatment on ischemia-reperfusion injuries in isolated rat hearts. Methods: Following 60 and 180 minutes of hyperoxia, rat hearts w...
full textPreconditioning effects of oxytocin in reducing cardiac arrhythmias in a rat heart regional ischemia-reperfusion model
Abstract Introduction: Occurrence of cardiac arrhythmias and myocardial infarction are two main deleterious events that are caused by ischemia-reperfusion (IR) injury in the heart. Cardiac preconditioning represents the most potent method of rescuing heart tissue from undergoing irreversible ischemic damage. The aim of the present study was to evaluate oxytocin (OT) cardioprotective effect...
full textProtective effects of vitamin D on ischemia-reperfusion injury of the ovary in a rat model
Objective(s): The aim of the present study is to investigate probable acute effects of vitamin D on ischemia-reperfusion injury in the rat ovary.Materials and Methods: A group of 30 Wistar albino rats was divided into five groups of 6 each. Group 1: underwent laparotomy only and the ovaries were removed. Group 2: 3-hr ischemia followed by excision of the ovaries. Group 3: 3-hr ischemia and 3...
full textEffects of silibinin on hepatic warm ischemia-reperfusion injury in the rat model
Objective(s): Liver ischemia-reperfusion injuries (I/RI) are typically the main causes of liver dysfunction after various types of liver surgery especially liver transplantation. Radical components are the major causes of such direct injuries. We aimed to determine the beneficial effects of silibinin, a potent radical scavenger on liver I/RI.Materials...
full textPretreatment effects of metformin on behavioral manifestations of global ischemia/reperfusion injury in rats
Introduction: Metformin (MET) as an oral antidiabetic drug has pleiotropic effects such as antioxidative and neuroprotective properties. In the current study we aimed to investigate the probable effects of Pretreatment MET therapy in global ischemia-reperfusion in rats. Materials and Methods: In this study, 40 male Wistar rats (200-220 g) were used. Animals were randomly divided into four g...
full textAntioxidant and antiapoptotic effects of erdosteine in a rat model of ovarian ischemia-reperfusion injury
Objective(s): To evaluate the protective effect of erdosteine, an antiapoptotic and antioxidant agent, on torsion–detorsion evoked histopathological changes in experimental ovarian ischemia-reperfusion (IR) injury. Materials and Methods: Eighteen female Wistar albino rats were used in control, IR, and IR+Edosteine (IR-E) groups, (n=6 in each). The IR-E group received the erdosteine for seven da...
full textMy Resources
Save resource for easier access later
Journal title:
physiology and pharmacologyجلد ۱۲، شماره ۲، صفحات ۹۱-۱۰۰
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023